O uso do canabidiol em crianças com epilepsia resistente a medicamento e a diminuição na frequência das crises: revisão rápida / The use of cannabidiol in children with drug-resistant epilepsy and the decrease in the frequency of seizures: quick review

Uso de canabidiol (CDB) medicinal presente no óleo de canabis. Indicação: Tratamento de crianças portadoras de epilepsia refratária resistente a medicação e síndromes graves decorrentes. Pergunta: O uso do canabidiol em crianças com epilepsia resistente a medicamentos apresentaria diminuição na frequência de crises convulsivas? Objetivo: Investigar a eficácia e a segurança do canabidiol, em comparação a placebo, na manutenção da remissão em crianças com epilepsia refratária. Métodos: Revisão rápida de revisões sistemáticas, por meio de buscas bibliográficas realizadas nas bases PUBMED, SCOPUS, BVS, Cochrane Library. Foram utilizadas estratégias de buscas com vocabulário padronizado e avaliação da qualidade metodológica usando o checklist AMSTAR 2. Resultados: Foram selecionadas duas revisões sistemáticas que atendiam aos critérios de elegibilidade. O CDB quando comparado ao placebo reduziu 50% das convulsões para epilepsia refrataria (RR 1.69 [1.20 ­ 2.36]), para a síndrome de Lennox-Gastaut o RR foi 2.98 (IC 95%, 1.83 - 4.85) e para a síndrome de Dravet o RR foi 2.26 (IC 95% ,1.38 - 3.70). O CDB pode resultar em uma diminuição no apetite em dosagens maiores (RR = 2,10, IC 95% [0,96­4,62], embora não apresente diferença de efeito dos grupos comparadores. Conclusão: Duas revisões sistemáticas recentes o CDB quando comparado ao placebo reduziu 50% das convulsões para epilepsia refrataria e síndromes graves. Entretanto, existem poucos ensaios clínicos publicados na área

: Use of cannabidiol (CBD) present in cannabis oil. Indication: Treatment of children with drug-resistant refractory epilepsy and severe syndromes resulting. Question: Would the use of cannabidiol in children with drug-resistant epilepsy lead to a decrease in seizure frequency? Objective: to investigate the efficacy and safety of cannabidiol, compared to placebos, in maintaining remission in children with refractory epilepsy. Methods: Rapid review of systematic reviews, through a bibliographical search carried out in the PUBMED, SCOPUS, BVS, Cochrane Library databases. Predefined search strategies were followed, and the methodological quality of the included studies was evaluated using the AMSTAR 2 tool. Results: Two systematic reviews were selected, which met the eligibility criteria. CBD when compared to placebo reduce 50% of seizures for refractory epilepsy (RR 1.69, IC 95% [1.20 ­ 2.36]), for Lennox-Gastaut Syndrome the RR was foi 2.98 (IC 95%, 1.83 - 4.85) and for Dravet Syndrome o RR FOI 2.26 (IC 95% ,1.38 - 3.70). CBD may result in appetite decrease using high doses (RR = 2.10, 95% IC [0.96­ 4.62], with no statistical difference. Conclusion: Two recent systematics, CBD, when compared to placebo, presented 50% of seizures for refractory epilepsy and severe syndromes. However, there are few clinical trials published in the area

Impact of dietary vitamin A deficiency on body physiology and liver metabolism of Wistar rats.

Background: Studies suggest that vitamin A deficiency (VAD) can cause night blindness or xerophthalmia, hepatic and metabolic changes in the blood. Aim: Therefore, this work aimed to stablish a model of hypovitaminosis A in rats and to evaluate the effects of vitamin A deficiency on metabolic and oxidative parameters in the liver of rats. Methods: Male (n = 19), Wistar, rats (21-day-old) weighing 50g, divided into two experimental groups: Control Group (C), received AIN 93G diet and Vitamin A Deficiency Group (VAD), received AIN 93G vitamin A-free diet for 45 days. In this work, the parameters analyzed were: body mass, food and water intake, biochemical aspects in the blood, lipids and glycogen content, lipid peroxidation, carbonyl proteins and catalase activity in the liver. Results: In the VAD group, final body mass (9%), liver mass (28%), glycemia (14%), Total -cholesterol (17%), HDL -cholesterol (31%) and VLDL -cholesterol (30%) showed reduced (p < 0.05). The liver lipid (64%) and glyceride-fatty acid (74%) contents were higher in the VAD group. The carbonyl proteins in liver were increased by 171% (p < 0.05). Conclusion: In summary, these results suggest that the absence of vitamin A from the diet was effective in inducing characteristics of hypovitaminosis A in rats. This way, can be used for studies related to glucose and lipid metabolism.